Yes.

Windows

Click on the Start menu, select "Run", type "mmsys.cpl" and click "OK". The audio settings window will open.

At the [Playback] tab, select "DJM-900NXS2". Audio signals will be sent to the Channel 1of this DJM. Signals cannot be sent to other channels.

*This cannot be used at the same time with the ASIO driver.

Mac OS

Open [System Preferences] > [Sound] > [Output] and select "DJM-900NXS2" from the list of sound output devices.

Open the Audio MIDI Setup application located in Utilities. Select "DJM-900NXS2". You can change output channel for this DJM by using [Configure Speakers ...] dialog.